{"id":3125,"date":"2018-12-21T12:10:43","date_gmt":"2018-12-21T12:10:43","guid":{"rendered":"http:\/\/www.citiusminds.com\/blog\/?p=3125"},"modified":"2021-02-09T09:35:04","modified_gmt":"2021-02-09T15:35:04","slug":"bictegravir-helps-to-block-hiv-infection","status":"publish","type":"post","link":"https:\/\/www.citiusminds.com\/blog\/bictegravir-helps-to-block-hiv-infection\/","title":{"rendered":"Bictegravir helps to block HIV infection"},"content":{"rendered":"\n

HIV (Human Immunodeficiency Virus) directly damages the immune system when it enters the human body. The immune system tries to fight the infection but the body does not show any symptoms in the initial stage, thereby silently killing most of the cells associated with the immune system i.e. CD4 cells. This causes various other infections in the body and may also lead to cancer. The HIV is transmitted mainly through bodily fluids that include blood, semen, and breast milk, vaginal and rectal fluids.<\/p>\n\n\n\n

HIV is a\nlifelong condition and currently, there is no permanent treatment for it.\nHowever, HIV infection can be treated in the initial stages. An HIV positive person\nif not treated can develop a serious condition called AIDS (acquired immune\ndeficiency syndrome). In this stage, the body\u2019s immune system becomes too weak\nand is unable to fight off other diseases or infections and drastically reduces\nthe life expectancy of a person to 3 years. Whereas, an HIV infected person\nwith proper treatment can have a life expectancy same as a person with no HIV\ninfection. Many therapies and drugs have been developed for fighting HIV\/AIDS,\nbut there is no permanent cure as of now.<\/p>\n\n\n\n

Recently, the U.S.\nFood and Drug Administration has given approval to a new drug called Bictegravir\nfor treating HIV infections. Bictegravir belongs to a group of HIV drugs called\nintegrase inhibitors. It blocks an HIV enzyme known as integrase and prevents\nthe infection from multiplying.<\/p>\n\n\n\n

Concert\nPharmaceuticals, a clinical stage biopharmaceutical company, recently got\npublished a new patent application no WO2018005328A1<\/strong><\/a>titled as \u201cDeuterated Bictegravir\u201d.\nThis patent application discloses the deuterated forms of Bictegravir and its\npharmaceutically acceptable salts thereof with below mentioned formula and its\nmethod of administration.<\/p>\n\n\n\n

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Compound 1<\/figcaption><\/figure><\/div>\n\n\n\n

The patent\napplication in one embodiment discloses the use of Bictegravir in methods of\ntreating diseases and conditions related to HIV infection. It also provides\nvarious methods to inhibit the activity of HIV infection enzyme called integrase.\nThe chemical name of Bictegravir is\n(2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13-,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]\npyrazino[2,1-b][1,3]oxazepine-1-0-carboxamide. Code names of Bictegravir are\nS-9883 and GS-9883-001, they are potent inhibitors of integrase that rapidly\nreduce HIV infection in humans.<\/p>\n\n\n\n

According to the\npatent application, Bictegravir is currently under Phase III clinical trials\nfor the treatment of HIV-1 infection and it has been tested for safety efficacy\nin the antiretroviral treatment of HIV infected adults as a fixed combination\nwith emtricitabine\/tenofovir alafenamide.<\/p>\n\n\n\n

In another embodiment, the patent application also discloses pharmaceutical compositions that comprise an effective amount of the disclosed compound and a pharmaceutically acceptable carrier like ion exchangers, alumina, aluminum stearate, lecithin, serum proteins, such as human serum albumin, buffer substances such as phosphates (e.g., phosphate-buffered saline, etc.). It can be administered orally and available as discrete units like capsules, sachets,tablets (which contains a predetermined amount of compound), powder or granules, solution or suspension in a liquid. The compound can also be administered in the form of suppositories for rectal administration or nasal aerosol or inhalation. <\/p>\n\n\n\n

Although the HIV infection or AIDS cannot be fully cured but the compositions of Bictegravir explained in this patent are highly effective in reducing the HIV infection quickly therefore preventing the HIV infection from spreading into the whole body thereby increasing the life expectancy of patients.<\/p>\n","protected":false},"excerpt":{"rendered":"

HIV (Human Immunodeficiency Virus) directly damages the immune system when it enters the human body. The immune system tries to fight the infection but the body does not show any symptoms in the initial stage, thereby silently killing most of the cells associated with the immune system i.e. CD4 cells. This causes various other infections […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[30,44,511],"class_list":["post-3125","post","type-post","status-publish","format-standard","hentry","category-latest-from-the-greatest","tag-patent","tag-patent-application","tag-treatment"],"_links":{"self":[{"href":"https:\/\/www.citiusminds.com\/blog\/wp-json\/wp\/v2\/posts\/3125","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.citiusminds.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.citiusminds.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.citiusminds.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.citiusminds.com\/blog\/wp-json\/wp\/v2\/comments?post=3125"}],"version-history":[{"count":0,"href":"https:\/\/www.citiusminds.com\/blog\/wp-json\/wp\/v2\/posts\/3125\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.citiusminds.com\/blog\/wp-json\/wp\/v2\/media?parent=3125"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.citiusminds.com\/blog\/wp-json\/wp\/v2\/categories?post=3125"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.citiusminds.com\/blog\/wp-json\/wp\/v2\/tags?post=3125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}